AW and you can JC developed and you will structured the analysis. AW drafted the fresh new manuscript. BC did research administration. BC and you may PN performed mathematical analyses. AW and you will JC made certain venture and read administration. All article writers (AW, PN, ML, BC, TP, LD, ALB, IY, SFo, SFr, and you may JC) resulted in translation of analysis and you will changed the newest manuscript. The experts approved the past manuscript. The fresh relevant journalist (AW) attests that every detailed article writers satisfy writing conditions and that zero others appointment the brand new criteria had been omitted. AW and JC certainly are the guarantors.
Funding: This research is financed of the French Federal Health insurance Financing (CNAM) in addition to Fitness Unit Epidemiology Scientific Interest Class (ANSM-CNAM EPI-PHARE SIG). AW, JC, and you will BC is staff regarding French National Health insurance Loans, PN is actually a member of staff of your own French National Service to possess Drugs and you can Wellness Things Safety. The current report signifies brand new views of one’s article writers and you may do never mirror the career of their businesses.
Competing hobbies: All experts have finished the fresh new ICMJE uniform disclosure mode during the and declare: help away from French National Medical insurance Finance (CNAM) as well as the Wellness Unit Epidemiology Scientific Appeal Classification (ANSM-CNAM EPI-PHARE SIG) towards submitted performs; no financial dating which have people companies which may are interested on the submitted work in the last 36 months; hardly any other relationships or things that will seem to have influenced the new recorded works.
Top honors journalist (AW) affirms that the manuscript is actually an honest, precise and you can transparent account of your studies getting said; one to no key factors of your research had been excluded; which any inaccuracies regarding data once the planned (and you may, when the related, registered) have been said.
Dissemination to players and you can relevant patient and you can personal communities: The outcome was in fact made available to diligent relationship representatives. People who’d put cyproterone acetate mg across the earlier in the day several decades (as well as their general therapists) obtained an information letter at your home delivering detailed information on which doing (secondary issue S18).
Set of accepted indicators into the people and you can ladies and you will revenue out-of highest amount cyproterone acetate (ten milligrams and you can 50 mg) by country from inside the European countries
Investigation communities
A couple of most other awareness analyses was in fact used: investigation of 2007-fourteen established otherwise control category head cohort have been paired to possess age at initiation and you can lifetime of follow-up, and you will a great nested situation-control study on new 2007-14 chief cohort.
Efficiency
Chance, cousin chance, and adjusted hazard ratio out-of meningioma based on experience of cyproterone acetate (chief cohort, 2007-14; n=253 777)
The new estimated amount of people with meningioma due to cyproterone https://datingmentor.org/escort/greensboro/ acetate try more than 500 within the France with the months 2007-fifteen (62 a-year; supplementary thing S16). That it estimate is based on an old-fashioned computation that does not account fully for people with an analysis multiple year immediately after discontinuation away from cyproterone acetate, people who have a diagnosis just after a primary group off really a little unsealed (control category) and you may next resumption out-of cyproterone acetate, and meningiomas addressed by the scientific pursue-right up in place of functions otherwise radiation therapy.
At exactly the same time, the clear presence of progesterone receptors for the arachnoid cells, where meningiomas happen, has been noted for five years.5556575859 Numerous article authors has stated a heterogeneous shipping out of progesterone receptors depending on the website out of meningiomas. A good rostrocaudal gradient from progesterone receptors, which have a high density out of receptors regarding the head feet, features commonly become advertised, and you can are verified by several books.6061 Our very own wanting of good predominance away from prior skull legs meningiomas linked to entry to cyproterone acetate, good progestogen, are in keeping with these biological results.
Advantages from the investigation
Several restrictions in addition to matter the fresh new clinical and you can histological characteristics away from meningioma. SNDS doesn’t consist of studies for the consequence of magnetized resonance imaging or histology, otherwise if meningiomas try solitary or multiple, with the exception of functions that involve distinct anatomical countries.
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